Adiff Aqueous Gel 15gm

INTRODUCTION

ADIFF contains Adapalene which belongs to the group of medicines called retinoic acid derivatives. It is used for the topical treatment of acne vulgaris in patients aged 12 years or older. It can be applied on the face, neck and back where the skin has lots of pimples, blackheads and dark spots. Acne vulgaris is a common skin condition that occurs in teens, when hair follicles of the skin plug with oil and dead skin cells. Symptoms includes inflammation, large, reddish pus-filled pimples and formation of comedones. Adapalene modulates keratinization and differentiation of follicular epithelial cells. It also has anti-inflammatory action which reduces soreness and irritation on the skin surface and reduces acne outbreaks. Along with the treatment, avoid exposure to sunlight or other artificial UV light as much as possible.

Apply a thin film of this medicine on the affected areas of the face and/or trunk. Do not apply this medicine on cut or scraped skin. After using this medicine continuously for 3 months, it is important to consult the doctor for accessing the improvements. Do not apply too much of this medicine, as it may result in skin irritation. The most common side effect of applying this medicine are dry skin, skin irritation or redness and burning sensation. Contact your doctor if any of these symptom bothers you. Do not use this medicine if you are pregnant. Consult your doctor before application. Although, application of ADIFF is considered safe in breastfeeding women, avoid applying on the chest to avoid contact exposure for infants.

• Treats acne, blackheads, spots and photo-aging

Adapalene directly binds to the nuclear retinoic acid receptors of the skin and modulates keratinization and differentiation of follicular epithelial cells. It promotes lysis of keratinocytes, prevents horny cells from binding to each other and stimulates epidermal cell turnover. It also has anti-inflammatory action which reduces soreness and irritation on the skin surface and reduces the outbreaks of acne.

Apply this medicine once or twice daily on the affected skin area, usually before going to bed or as directed by your physician. It is for external use only. Before application, wash the affected area with a mild, non-medicated soap. Pat the skin dry. Apply a thin film of this medicine on the affected areas of the face and/or trunk.

Do not apply this medicine on wounded, damaged, cut or scraped skin. Avoid contact of this medicine with eyes, ears, nose, mouth or other very sensitive areas of the body. If contact happens, rinse it thoroughly with water. Your doctor will decide the correct dose and duration of therapy for you depending upon how your acne responds. Continue to apply this medicine, as long as your doctor tells you to do so, to obtain better results.

Skin irritation:

Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizers to soothe and hydrate the affected area. If it does not get better, speak to a doctor.

INTERACTIONS

Talk to your doctor, if you are taking:

• Other medicines used to treat acne (e.g. benzoyl peroxide, tretinoin, erythromycin, clindamycin)
• Cosmetics containing alcohol, lime and spices (e.g. after-shave lotions, soaps, shampoos or perfumes)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

Can ADIFF remove acne scars?

Yes. This medicine modulates keratinization and differentiation of follicular epithelial cells. It can remove acne scars, dark spots and blackheads.

Can ADIFF be used twice a day?

Yes. Apply this medicine once or twice daily on the affected skin area, usually before going to bed or as directed by your physician.

Is it safe to use ADIFF during pregnancy?

No. It is strictly not recommended for use in pregnant women. Consult your doctor before taking.

1. KD. Tripathi. Drugs Acting on Skin and Mucous Membranes. Essentials of medical pharmacology. Seventh edition. 2013. Page – 894.

2. Craig Burkhart, Dean Morrell and Lowell Goldsmith. Dermatological Pharmacology. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1810.

3. Gerald G. Briggs and Roger K. Freeman. A. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 93-94.

4. Galderma. Clinical Study to Test the Efficacy and Safety of Adapalene, 0.1%. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2011] [Accessed 4th December 2020]

5. Suleyman Piskin and Erol Uzunali. A review of the use of adapalene for the treatment of acne vulgaris. NCBI; PMC US National Library of Medicine, National Institute of Health. August 2007. [Accessed 4th December 2020]

6. Gladerma Laboratories. Electronic Medicines Compendium (EMC); [Revised on June 2020] [Accessed 4th December 2020]

7. Gladerma Laboratories. U.S. Food & Drug Administration. [Revised on January 2013] [Accessed 4th December 2020]